Diamicron MR 60 mg Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Gliclazide

Indications/Uses

NIDDM (type 2) in adults when dietary measures, physical exercise & wt loss alone are not sufficient to control blood glucose.

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Dosage/Direction for Use

Initially 30 mg daily (½ tab). If blood glucose is inadequately controlled, dose may be increased to 60, 90 or 120 mg daily in successive steps w/ at least 1-mth interval. Max: 120 mg daily. Patient at risk of hypoglycaemia Initially 30 mg daily. Switching from another oral antidiabetic agent Initially 30 mg daily.

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Overdosage

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Administration

Should be taken with food: Take w/ breakfast. Swallow whole, do not chew/crush.

Contraindications

Hypersensitivity to gliclazide, other sulfonylureas, sulfonamides. Type 1 diabetes. Diabetic pre-coma & coma, diabetic ketoacidosis. Concomitant use w/ miconazole. Severe renal or hepatic insufficiency. Lactation.

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Special Precautions

Increased risk of hypoglycaemia due to low-calorie diet, prolonged or strenuous exercise, alcohol intake or if used w/ other hypoglycaemics; malnutrition, irregular mealtimes, skipping meals, fasting or dietary changes; imbalance between physical exercise & carbohydrate intake; overdosage; thyroid disorders, hypopituitarism & adrenal insufficiency. G6PD deficiency. Dysglycaemia; porphyria. Ensure appropriate diet & regular physical exercise. Regularly monitor blood glucose levels & glycated Hb levels. Concomitant use w/ St. John's wort (Hypericum perforatum), fluoroquinolones. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Renal & hepatic insufficiency. Avoid use during pregnancy. Childn & adolescents. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypoglycaemia; GI disturbances eg, abdominal pain, nausea, vomiting, dyspepsia, diarrhoea, constipation.

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Drug Interactions

Increased hypoglycaemic effect w/ miconazole systemic/oromucosal gel, systemic phenylbutazone, alcohol. Potentiated blood glucose-lowering effect w/ other antidiabetic agents (insulins, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, GLP-1 receptor agonists), β-blockers, fluconazole, ACE inhibitors (captopril, enalapril), H₂-receptor agonists, MAOIs, sulfonamides, clarithromycin, NSAIDs. Diabetogenic effect of danazol. Increased blood glucose levels w/ chlorpromazine, glucocorticoids, ritodrine, salbutamol, terbutaline IV. Decreased exposure by St. John's wort. Risk of dysglycaemia w/ fluoroquinolones. Potentiated anticoagulation w/ warfarin.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BB09 - gliclazide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

Regulatory Classification

Presentation/Packing

Form

Diamicron MR 60 mg MR tab

Packing/Price

30's;60's

Diamicron MR 60 mg

gliclazide

Manufacturer:

Servier

Distributor:

Zuellig Pharma